Article
The Met allele of the BDNF Val66Met polymorphism predicts poor outcome among survivors of aneurysmal subarachnoid hemorrhage.
Stroke - 1 Oct 2007
Siironen Jari, Juvela Seppo, Kanarek Katarzyna, Vilkki Juhani, Hernesniemi Juha, Lappalainen Jaakko
Abstract excerpt
BACKGROUND AND PURPOSE: Brain-derived neurotrophic factor (BDNF) plays a role in neuronal survival, plasticity and neurogenesis. The BDNF gene contains a common Val66Met polymorphism; the Met allele is associated with lower depolarization-induced BDNF release and differences in memory functions and brain morphology. We hypothesized that the Met allele is associated with poor recovery from subarachnoid hemorrhage....
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