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Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation.

Stroke - 1 Aug 2012

Westbroek Erick M, Pawlikowska Ludmila, Lawton Michael T, McCulloch Charles E, Young William L, Kim Helen

Abstract excerpt

BACKGROUND AND PURPOSE: The Val66Met polymorphism of brain-derived neurotrophic factor is associated with decreased brain-derived neurotrophic factor secretion and poor outcome after acute neurological injury. We hypothesized that the Met allele is associated with worsening of functional outcome after brain arteriovenous malformation resection. METHODS: Three hundred forty-one surgically treated patients with...

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Identifiers

PMID: 22773554
DOI: 10.1161/STROKEAHA.112.663096
PMCID: PMC3431194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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