Article
A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Kim Kevin K, Flaherty Kevin R, Long Qi, Hattori Noboru, Sisson Thomas H, Colby Thomas V, Travis William D, Martinez Fernando J, Murray Susan, Simon Richard H
Abstract excerpt
The normal fibrinolytic activity within the alveolar space is suppressed in fibrotic lung diseases in part because of increased levels of plasminogen activator inhibitor-1 (PAI-1). Studies with animals have shown that inhibition of the plasminogen system by PAI-1 increases the generation of pulmonary fibrosis. To determine if a similar relationship occurs in human fibrotic lung diseases, we took advantage of a...
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