Article
PKA from Mucor circinelloides: model to study the role of linker I in the interaction between R and C subunits.
Biochemical and biophysical research communications - 26 Oct 2007
Ocampo Josefina, Moreno Silvia, Rossi Silvia
Abstract excerpt
Protein kinase A from the fungus Mucor circinelloides shows high affinity interaction between regulatory (R) and catalytic (C) subunits. Its R subunit shows a differential presence of several acidic residues in linker I region, in the amino terminus. Mutants R1, lacking the N-terminal region, and R2, lacking the acidic cluster, were used to analyze its effect on the interaction with the C subunit, assessed...
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