PCR analysis of dystrophin gene mutation and expression.

doi:10.1002/jcb.240460309

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Article

PCR analysis of dystrophin gene mutation and expression.

Journal of cellular biochemistry - 1 Jul 1991

Chamberlain J S, Farwell N J, Chamberlain J R, Cox G A, Caskey C T

Abstract excerpt

Duchenne muscular dystrophy (DMD) is caused by mutations that impair normal production of dystrophin in muscle and brain tissues. The dystrophin gene is expressed at extremely low levels in both humans and mice, which makes analysis of the 14kb mRNA a difficult task. In addition, 30% of all cases...

Topics

Animals
Base Sequence
Brain
Dystrophin
Exons
Gene Expression
Genotype
Mice
Molecular Sequence Data
Muscles
Muscular Dystrophy, Animal
Mutation
Polymerase Chain Reaction
RNA, Messenger
Transcription, Genetic

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