Analysis of a dystrophin gene deletion by amplification of mRNA isolated from DMD myotubes cultured in vitro.

doi:10.1016/0888-7543(91)90435-h

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Article

Analysis of a dystrophin gene deletion by amplification of mRNA isolated from DMD myotubes cultured in vitro.

Genomics - 1 Jul 1991

Ehrenpreis J, Hillers M, Junkes B, Pfordt M, Schwinger E, Vosberg H P

Abstract excerpt

The most frequent causes for the X-linked muscular dystrophy of the allelic Duchenne (DMD) or Becker (BMD) type are partial deletions of the dystrophin gene. These mutations are accompanied either by disrupted or by preserved translational reading frames in mRNAs derived from the deleted genes. A...

Topics

Base Sequence
Cells, Cultured
Child
Dystrophin
Exons
Frameshift Mutation
Genes
Humans
Male
Molecular Sequence Data
Muscles
Muscular Dystrophies
Mutation
Polymerase Chain Reaction
RNA, Messenger

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