Article
Polymorphisms in adenosine receptor genes are associated with infarct size in patients with ischemic cardiomyopathy.
Clinical pharmacology and therapeutics - 1 Oct 2007
Tang Z, Diamond M A, Chen J-M, Holly T A, Bonow R O, Dasgupta A, Hyslop T, Purzycki A, Wagner J, McNamara D M, Kukulski T, Wos S, Velazquez E J, Ardlie K, Feldman A M
Abstract excerpt
The goal of this experiment was to identify the presence of genetic variants in the adenosine receptor genes and assess their relationship to infarct size in a population of patients with ischemic cardiomyopathy. Adenosine receptors play an important role in protecting the heart during ischemia and in mediating the effects of ischemic preconditioning. We sequenced DNA samples from 273 individuals with ischemic...
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