Article
A nonsynonymous variant I248L of the adenosine A3 receptor is associated with coronary heart disease in a Latvian population.
DNA and cell biology - 1 Nov 2011
Peculis Raitis, Latkovskis Gustavs, Tarasova Linda, Pirags Valdis, Erglis Andrejs, Klovins Janis
Abstract excerpt
Adenosine plays an important part in the cardiac response to ischemia and reperfusion. The human adenosine receptor A3 (A3R), along with other adenosine receptors, is involved in mediation of those effects. The aim of the study was to ascertain whether the nonsynonymous single-nucleotide polymorphism (SNP) I248L (reference SNP ID: rs35511654) located in the A3R gene is associated with coronary heart disease...
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