Article
Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample.
Psychiatric genetics - 1 Oct 2007
Georgi Alexander, Jamra Rami Abou, Klein Katrin, Villela Angela Wolf, Schumacher Johannes, Becker Tim, Paul Torsten, Schmael Christine, Höfels Susanne, Klopp Norman, Illig Thomas, Propping Peter, Cichon Sven, Nöthen Markus M, Schulze Thomas G, Rietschel Marcella
Abstract excerpt
Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methyl-D-aspartate receptor subunit gene GRIN1 has been proposed as a candidate gene for schizophrenia. We tested for a potential association between schizophrenia and four single nucleotide polymorphisms (rs4880213, rs11146020, rs6293, and rs10747050) and one microsatellite...
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