Article
No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample.
Psychiatric genetics - 1 Oct 2006
Georgi Alexander, Jamra Rami A, Schumacher Johannes, Becker Tim, Schmael Christine, Deschner Monika, Höfels Susanne, Wulff Maren, Schwarz Markus, Klopp Norman, Illig Thomas, Propping Peter, Cichon Sven, Nöthen Markus M, Rietschel Marcella, Schulze Thomas G
Abstract excerpt
Disturbed glutamatergic neurotransmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder, with the N-methy-D-aspartate receptors being in the focus of research. The NR1 subunit, which is encoded by the gene GRIN1, plays a key role in the functionality of N-methy-D-aspartate receptors. We tested the association between GRIN1 and bipolar disorder in a sample of German descent,...
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