Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus.

Journal of virology - 1 Nov 2007

Hwang Jae-Seon, Kregler Oliver, Schilf Rita, Bannert Norbert, Drach John C, Townsend Leroy B, Bogner Elke

Abstract excerpt

DNA packaging is the key step in viral maturation and involves binding and cleavage of viral DNA containing specific DNA-packaging motifs. This process is mediated by a group of specific enzymes called terminases. We previously demonstrated that the human cytomegalovirus (HCMV) terminase is composed of the large subunit pUL56 and the small subunit pUL89. While the large subunit mediates sequence-specific DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acylation
Share to Antiviral Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Benzimidazoles

Share to Cytomegalovirus

Share to Drug Evaluation, Preclinical

Share to Inhibitory Concentration 50

Share to Microscopy, Electron, Transmission

Share to Models, Chemical

Source

Open in PubMed Open full text

Identifiers

PMID: 17728228
DOI: 10.1128/JVI.01130-07
PMCID: PMC2168816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus.PMID 17728228Read ↗

Resistance of Human Cytomegalovirus to Benzimidazole Ribonucleosides Maps to Two Open Reading Frames: UL89 and UL56Semantic proximity Read ↗

Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product.Semantic proximity Read ↗

Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides.Semantic proximity Read ↗

Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.Semantic proximity Read ↗

Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome CleavageSemantic proximity Read ↗

DNA encapsidation as a target for anti-herpesvirus drug therapy.Semantic proximity Read ↗

The Novel Anticytomegalovirus Compound AIC246 (Letermovir) Inhibits Human Cytomegalovirus Replication through a Specific Antiviral Mechanism That Involves the Viral TerminaseSemantic proximity Read ↗

Human cytomegalovirus terminase as a target for antiviral chemotherapySemantic proximity Read ↗

Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of actionSemantic proximity Read ↗

The human cytomegalovirus terminase complex as an antiviral target: a close-up viewSemantic proximity Read ↗

Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.Semantic proximity Read ↗

Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 GeneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.