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Article

Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.

Antimicrobial agents and chemotherapy - 1 Jan 2015

Gentry Brian G, Phan Quang, Hall Ellie D, Breitenbach Julie M, Borysko Katherine Z, Kamil Jeremy P, Townsend Leroy B, Drach John C

Abstract excerpt

Human cytomegalovirus (HCMV) infection can cause severe illnesses, including encephalopathy and mental retardation, in immunocompromised and immunologically immature patients. Current pharmacotherapies for treating systemic HCMV infections include ganciclovir, cidofovir, and foscarnet. However, long-term administration of these agents can result in serious adverse effects (myelosuppression and/or nephrotoxicity)...

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Identifiers

PMID: 25348532
DOI: 10.1128/AAC.03686-14
PMCID: PMC4291354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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