Article
Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides.
Journal of virology - 1 Jan 2004
Komazin Gloria, Townsend Leroy B, Drach John C
Abstract excerpt
The benzimidazole D-ribonucleosides TCRB and BDCRB are potent and selective inhibitors of human cytomegalovirus (HCMV) replication. Two HCMV strains resistant to these compounds were selected and had resistance mutations in genes UL89 and UL56. Proteins encoded by these two genes are the two subu...
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