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Article

Centriole separation in DNA damage‐induced centrosome amplification

9 Mar 2009

Abstract excerpt

Altered centrosome numbers are seen in tumor cells in response to DNA damaging treatments and are hypothesised to contribute to cancer development. The mechanism by which the centrosome and chromosome cycles become disconnected after DNA damage is not yet clear. Here, we show that centrosome amplification occurs after ionising radiation (IR) in chicken DT40 cells that lack DNA-PK, Ku70, H2AX, Xpa, and Scc1,...

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PMID: 19274769
DOI: 10.1002/em.20477

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