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Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide

8 Dec 2011

Abstract excerpt

BACKGROUND: Over the last decade, several drugs that inhibit class I and/or class II histone deacetylases (HDACs) have been identified, including trichostatin A, the cyclic depsipeptide FR901228 and the antibiotic apicidin. These compounds have had immediate application in cancer research because of their ability to reactivate aberrantly silenced tumour suppressor genes and/or block tumour cell growth. Although a...

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PMID: 22158273
DOI: 10.1038/bjc.2011.532

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