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Article

The role of electrostatics in colicin nuclease domain translocation into bacterial cells.

The Journal of biological chemistry - 26 Oct 2007

Walker Daniel, Mosbahi Khédidja, Vankemmelbeke Mireille, James Richard, Kleanthous Colin

Abstract excerpt

The mechanism(s) by which nuclease colicins translocate distinct cytotoxic enzymes (DNases, rRNases, and tRNases) to the cytoplasm of Escherichia coli is unknown. Previous in vitro investigations on isolated colicin nuclease domains have shown that they have a strong propensity to associate with anionic phospholipid vesicles, implying that electrostatic interactions with biological membranes play a role in their...

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PMID: 17720814
DOI: 10.1074/jbc.M705883200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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