Article
Individualizing amikacin regimens: accurate method to achieve therapeutic concentrations.
Therapeutic drug monitoring - 1 Nov 1991
Zaske D E, Cipolle R J, Rotschafer J C, Kohls P R, Strate R G
Abstract excerpt
Amikacin's pharmacokinetics and dosage requirements were studied in 98 patients receiving treatment for gram-negative infections. A wide interpatient variation in the kinetic parameters of the drug occurred in all patients and in patients who had normal serum creatinine levels or normal creatinin...
Topics
- Adult
- Aged
- Aging
- Amikacin
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Genetic Variation
- Gram-Negative Bacterial Infections
- Humans
- Kidney
- Male
- Middle Aged
- Models, Biological