Article
Pharmacokinetics and safety of intravenous voriconazole in children after single- or multiple-dose administration.
Antimicrobial agents and chemotherapy - 1 Jun 2004
Walsh Thomas J, Karlsson Mats O, Driscoll Timothy, Arguedas Adriano G, Adamson Peter, Saez-Llorens Xavier, Vora Ajay J, Arrieta Antonio C, Blumer Jeffrey, Lutsar Irja, Milligan Peter, Wood Nolan
Abstract excerpt
We conducted a multicenter study of the safety, tolerability, and plasma pharmacokinetics of the parenteral formulation of voriconazole in immunocompromised pediatric patients (2 to 11 years old). Single doses of 3 or 4 mg/kg of body weight were administered to six and five children, respectively. In the multiple-dose study, 28 patients received loading doses of 6 mg/kg every 12 h on day 1, followed by 3 mg/kg...
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