Article
Monitoring serum levels of gentamicin to develop a new regimen for gentamicin dosage in newborns.
Therapeutic drug monitoring - 1 May 1991
Faura C C, Feret M A, Horga J F
Abstract excerpt
The newborns studied had gestational ages ranging between 23-44 weeks, weights ranging between 725-4510 g, and were treated with standard doses of gentamicin (5.2 +/- 1.0 mg/kg/day). The gentamicin serum peak and trough levels were unrelated to administered doses, and a large proportion of patients had low (peak less than 4 micrograms/ml in 12%) or potentially toxic concentrations (trough greater than 2...
Topics
- Analysis of Variance
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Monitoring
- Genetic Variation
- Gentamicins
- Humans
- Infant, Newborn
- Monitoring, Physiologic
- Multivariate Analysis
- Retrospective Studies