Beta-lactam dose reductions in critically ill patients with acute kidney injury: a scoping review

Abstract excerpt

<title>Abstract</title> <p>Background Acute kidney injury is a common complication in critically ill patients, often coinciding with the need for antibiotic therapy. The dose of beta-lactam antibiotics is frequently adjusted and often reduced based on estimated Glomerular Filtration Rate. However, early dose reductions may lead to underdosing, especially during the critical first 48 hours of infection treatment,...

Topics

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• Anti-Infective Agents
• Body Weight
• Dose-Response Relationship, Drug
• Drug Dosage Calculations
• Glomerular Filtration Rate
• Kidney Function Tests
• Metabolic Clearance Rate
• Renal Insufficiency

Identifiers and source

Literature Corpus work

55f3e666-4c10-504e-8eaf-abcdd32f5e3e

DOI

10.21203/rs.3.rs-7156465/v1