Article
[Interleukin-1, inflammasome and autoinflammatory diseases].
La Revue de medecine interne - 1 Apr 2018
Jamilloux Y, Bourdonnay E, Gerfaud-Valentin M, Py B F, Lefeuvre L, Barba T, Broussolle C, Henry T, Sève P
Abstract excerpt
Interleukin-1 is a major cytokine of innate immunity and inflammation. It exerts various systemic effects during the inflammatory response, such as fever induction, thrombopoiesis and granulopoiesis, or leukocyte recruitment. Its involvement has been demonstrated in many inflammatory-mediated diseases, such as diabetes or gout. Moreover, interleukin-1 plays a pivotal role in some autoinflammatory diseases, such...
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