Article
CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae.
Molecular microbiology - 1 Sept 2007
Ghugtyal Vikram, Vionnet Christine, Roubaty Carole, Conzelmann Andreas
Abstract excerpt
After glycosylphosphatidylinositols (GPIs) are added to GPI proteins of Saccharomyces cerevisiae, the fatty acid in sn-2 of the diacylglycerol moiety can be replaced by a C26:0 fatty acid by a deacylation-reacylation cycle catalysed by Per1p and Gup1p. Furthermore the diacylglycerol moiety of the yeast GPI anchor can also be replaced by ceramides. CWH43 of yeast is homologous to PGAP2, a gene that recently was...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Cell Wall
- Ceramides
- Fatty Acids
- Glycosylphosphatidylinositols
- Histidine
- Hydrolases
- Inositol
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Phosphoric Monoester Hydrolases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transfection