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Article

CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae.

Molecular microbiology - 1 Sept 2007

Ghugtyal Vikram, Vionnet Christine, Roubaty Carole, Conzelmann Andreas

Abstract excerpt

After glycosylphosphatidylinositols (GPIs) are added to GPI proteins of Saccharomyces cerevisiae, the fatty acid in sn-2 of the diacylglycerol moiety can be replaced by a C26:0 fatty acid by a deacylation-reacylation cycle catalysed by Per1p and Gup1p. Furthermore the diacylglycerol moiety of the yeast GPI anchor can also be replaced by ceramides. CWH43 of yeast is homologous to PGAP2, a gene that recently was...

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Source

Identifiers

PMID: 17714445
DOI: 10.1111/j.1365-2958.2007.05883.x

Genes

GPI
CWH43
PGAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae.PMID 17714445Read ↗

Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides.Semantic proximity Read ↗

Determination and physiological roles of the glycosylphosphatidylinositol lipid remodelling pathway in yeast.Semantic proximity Read ↗

GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.Semantic proximity Read ↗

Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi.Semantic proximity Read ↗

C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p.Semantic proximity Read ↗

Alternative lipid remodelling pathways for glycosylphosphatidylinositol membrane anchors in Saccharomyces cerevisiae.Semantic proximity Read ↗

Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity.Semantic proximity Read ↗

Identification of SPT14/CWH6 as the yeast homologue of hPIG-A, a gene involved in the biosynthesis of GPI anchors.Semantic proximity Read ↗

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