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Article

Identification of SPT14/CWH6 as the yeast homologue of hPIG-A, a gene involved in the biosynthesis of GPI anchors.

Biochimica et biophysica acta - 13 Apr 1995

Vossen J H, Ram A F, Klis F M

Abstract excerpt

Cwh6 is a temperature-sensitive cell wall mutant of Saccharomyces cerevisiae. CWH6 was found to be identical to SPT14, a gene that is highly homologous to both human PIG-A and to RFAK from Salmonella typhimurium. PIG-A and RFAK are involved in transferring N-acetylglucosamine to, respectively, a GPI anchor precursor and to lipopolysaccharides. Because cell walls of cwh6 are greatly reduced in mannose, and because...

Topics

Amino Acid Sequence
Cell Wall
Fungal Proteins
Glycosylphosphatidylinositols
Glycosyltransferases
Humans
Mannose
Molecular Sequence Data
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Salmonella typhimurium

Sequence Alignment

Sequence Homology

Trans-Activators

Source

Identifiers

PMID: 7727533
DOI: 10.1016/0304-4165(95)00002-s

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7727533-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification of SPT14/CWH6 as the yeast homologue of hPIG-A, a gene involved in the biosynthesis of GPI anchors.PMID 7727533Read ↗

Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis.Semantic proximity Read ↗

CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides.Semantic proximity Read ↗

Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity.Semantic proximity Read ↗

Genome‐wide identification of fungal GPI proteinsSemantic proximity Read ↗

Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene.Semantic proximity Read ↗

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Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi.Semantic proximity Read ↗

Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants.Semantic proximity Read ↗

GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.Semantic proximity Read ↗

Determination and physiological roles of the glycosylphosphatidylinositol lipid remodelling pathway in yeast.Semantic proximity Read ↗

The Schizosaccharomyces pombe GPI8 gene complements a Saccharomyces cerevisiae GPI8 anchoring mutant.Semantic proximity Read ↗

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