Article
Consequences of the JAK2V617F allele burden for the prediction of transformation into myelofibrosis from polycythemia vera and essential thrombocythemia.
International journal of hematology - 1 Feb 2015
Shirane Shuichi, Araki Marito, Morishita Soji, Edahiro Yoko, Sunami Yoshitaka, Hironaka Yumi, Noguchi Masaaki, Koike Michiaki, Sato Eriko, Ohsaka Akimichi, Komatsu Norio
Abstract excerpt
Patients diagnosed with polycythemia vera (PV) or essential thrombocythemia (ET) sometimes suffer transformation of the disease into myelofibrosis (MF), which is associated with a poorer prognosis. This study investigated the prognostic value of the allele burden of JAK2V617F, a somatic driver mutation in these diseases, by comparing the allele burden between formalin-fixed paraffin-embedded bone marrow collected...
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