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Article

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

1 Jan 2013

Abstract excerpt

The oncogenic epithelial-mesenchymal transition (EMT) contributes to tumor progression in various context-dependent ways, including increased metastatic potential, expansion of cancer stem cell subpopulations, chemo-resistance and disease recurrence. One of the hallmarks of EMT is resistance of tumor cells to anoikis. This resistance contributes to metastasis and is a defining property not only of EMT but also of...

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PMID: 23516327
DOI: 10.1242/jcs.120907

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