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Article

The Atg5–Atg12 conjugate associates with innate antiviral immune responses

20 Aug 2007

Abstract excerpt

Autophagy is an essential process for physiological homeostasis, but its role in viral infection is only beginning to be elucidated. We show here that the Atg5-Atg12 conjugate, a key regulator of the autophagic process, plays an important role in innate antiviral immune responses. Atg5-deficient mouse embryonic fibroblasts (MEFs) were resistant to vesicular stomatitis virus replication, which was largely due to...

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PMID: 17709747
DOI: 10.1073/pnas.0704014104

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