ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus

Abstract excerpt

Autophagy-related protein 7 (ATG7) is an essential autophagy effector enzyme. Although it is well known that autophagy plays crucial roles in the infections with various viruses including influenza A virus (IAV), function and underlying mechanism of ATG7 in infection and pathogenesis of IAV remain poorly understood. Here, in vitro studies showed that ATG7 had profound effects on replication of IAV. Depletion of...

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• Autophagy in Disease and Therapy
• Immune Cell Function and Interaction
• Mosquito-borne diseases and control