Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain.

doi:10.3727/000000006781510688

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Article

Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain.

Gene expression - 1 Jan 2007

Yool Andrea J

Abstract excerpt

The neurogenic protein Drosophila big brain (BIB), which is involved in the process of neuroblast determination, and the water channel aquaporin-1 (AQP1) are among a subset of the major intrinsic protein (MIP) channels that have been found to show gated monovalent cation channel activity. A glutamate residue in the first transmembrane (M1) domain is conserved throughout the MIP family. Mutation of this residue to...

Topics

Amino Acid Sequence
Animals
Aquaporin 1
Drosophila
Drosophila Proteins
Female
Genes, Dominant
Glutamic Acid
In Vitro Techniques
Ion Channels
Membrane Proteins
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Molecular Sequence Data

Mutation

Oocytes

Protein Structure, Tertiary

Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 17708419
DOI: 10.3727/000000006781510688
PMCID: PMC6032454

Genes

AQP1
MIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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