Article
Genetic analysis of ion channel dysfunction in Drosophila.
Kidney international - 1 Mar 2000
Ganetzky B
Abstract excerpt
To dissect the molecular mechanisms of electrical activity in the nervous system, an extensive collection of mutations affecting various types of voltage-gated ion channels was identified and characterized in Drosophila. Most of these mutations were generated by chemical mutagenesis and were recognized on the basis of defects in motor behavior. These were the first genetically determined ion channelopathies to be...
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