Article
Telomere dysfunction in peripheral lymphocytes as a potential predisposition factor for renal cancer.
The Journal of urology - 1 Oct 2007
Shao Lina, Wood Christopher G, Zhang Di, Tannir Nizar M, Matin Surena, Dinney Colin P, Wu Xifeng
Abstract excerpt
PURPOSE: Genetic integrity is maintained in part by the architecture of telomeres. We previously developed a laser scanning cytometry based quantitative fluorescence in situ hybridization assay to assess telomere length in peripheral blood lymphocytes. In this study we modified the assay by incorporating 9 control cell lines to normalize telomere length. MATERIALS AND METHODS: We applied this assay to 65 patients...
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