Telomere Length Abnormalities Occur Early in the Initiation of Epithelial Carcinogenesis

Abstract excerpt

PURPOSE: Telomeres help maintain chromosomal integrity. Dysfunctional telomeres can cause genetic instability in vitro and an increased cancer incidence in telomerase knock out mouse models. We recently reported that telomere shortening was a prevalent alteration in human prostate, pancreas, and breast cancer precursor lesions. In the present study, we address whether the previous findings are broadly applicable...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Epigenetics and DNA Methylation
• Share to Genetic factors in colorectal cancer
• Share to Telomeres, Telomerase, and Senescence