Article
Telomere dysfunction: a potential cancer predisposition factor.
Journal of the National Cancer Institute - 20 Aug 2003
Wu Xifeng, Amos Christopher I, Zhu Yong, Zhao Hua, Grossman Barton H, Shay Jerry W, Luo Sherry, Hong Waun Ki, Spitz Margaret R
Abstract excerpt
BACKGROUND: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between telomere length and cancer risk in four ongoing case-control studies. METHODS: All studies had equal numbers of case patients and matched control subjects (92 for head and neck cancer, 135 for bladder cancer, 54 for lung cancer, and 32 for renal...
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