Article
Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms.
Medical science monitor : international medical journal of experimental and clinical research - 1 Oct 2009
Saccucci Patrizia, Manca Bitti Maria Luisa, Bottini Nunzio, Rapini Novella, Piccinini Simona, D'Annibale Federica, Chiarelli Francesco, Verrotti Alberto, Bottini Egidio, Gloria-Bottini Fulvia
Abstract excerpt
BACKGROUND: ACP1 (acid phosphatase locus 1, a cytosolic low-molecular-weight phosphotyrosin phosphatase) and ADA1 (adenosine deaminase locus 1) are two polymorphic systems involved in immune reactions. Observed interactions at the biochemical and clinical levels between the two systems prompted this investigation of a possible interaction concerning susceptibility to type 1 diabetes. MATERIAL/METHODS: Two hundred...
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