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Article

Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer.

British journal of cancer - 17 Sept 2007

Agalliu I, Karlins E, Kwon E M, Iwasaki L M, Diamond A, Ostrander E A, Stanford J L

Abstract excerpt

Studies of families who segregate BRCA2 mutations have found that men who carry disease-associated mutations have an increased risk of prostate cancer, particularly early-onset disease. A study of sporadic prostate cancer in the UK reported a prevalence of 2.3% for protein-truncating BRCA2 mutations among patients diagnosed at ages < or =55 years, highlighting the potential importance of this gene in prostate...

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Identifiers

PMID: 17700570
DOI: 10.1038/sj.bjc.6603929
PMCID: PMC2360390

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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