Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase.

doi:10.1097/01.fpc.0000236333.49422.86

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Article

Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase.

Pharmacogenetics and genomics - 1 Sept 2007

Mikami Liya R, Wieseler Stacy, Souza Ricardo L R, Schopfer Lawrence M, Lockridge Oksana, Chautard-Freire-Maia Eleidi A

Abstract excerpt

The present paper examined the effects of three non synonymous BCHE mutations (G75R, E90D and /99M) on enzyme kinetic parameters obtained after the expression of the respective recombinant BChEs. The respective nucleotide substitution that characterizes each of the three variants was introduced into BCHE cDNA by site directed mutagenesis and transfected into human embryonic kidney 293 T cells and Chinese hamster...

Topics

Alzheimer Disease
Amino Acid Substitution
Animals
Butyrylcholinesterase
CHO Cells
Cell Line
Cricetinae
Cricetulus
Gene Expression
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Kinetics

Models, Molecular

Mutagenesis, Site-Directed

Pharmacogenetics

Phenotype

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 17700357
DOI: 10.1097/01.fpc.0000236333.49422.86

Genes

BCHE
BTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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