Article
A new approach to inhibiting astrocytic IP3-induced intracellular calcium increase in an astrocyte-neuron co-culture system.
Brain research - 7 Sept 2005
Saheki Yasunori, Li Sheng-Tian, Matsushita Masayuki, Wu Yu-Mei, Cai Wei-Hua, Wei Fan-Yan, Lu Yun-Fei, Moriwaki Akiyoshi, Tomizawa Kazuhito, Matsui Hideki
Abstract excerpt
Astrocytes exhibit dynamic Ca2+ mobilization, such as Ca2+ wave and Ca2+ oscillation, via an inositol 1,4,5-triphosphate-induced Ca2+ release (IICR)-dependent mechanism. The physiological functions of astrocytic Ca2+ mobilization, however, are poorly understood. To investigate this issue, we created a plasmid encoding an enhanced green fluorescent protein-tagged inositol 1,4,5-triphosphate absorbent protein and...
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