Article
Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2003
Ciccolini Francesca, Collins Tony J, Sudhoelter Juliana, Lipp Peter, Berridge Michael J, Bootman Martin D
Abstract excerpt
Neural stem cells can generate in vitro progenitors of the three main cell lineages found in the CNS. The signaling pathways underlying the acquisition of differentiated phenotypes in these cells are poorly understood. Here we tested the hypothesis that Ca(2+) signaling controls differentiation of neural precursors. We found low-frequency global and local Ca(2+) transients occurring predominantly during early...
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