Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70).

Scientific reports - 12 Apr 2018

Ben-Menachem Reut, Wang Katherine, Marcu Orly, Yu Zhang, Lim Teck Kwang, Lin Qingsong, Schueler-Furman Ora, Pines Ophry

Abstract excerpt

Molecules of single proteins, echoforms, can be distributed between two (or more) subcellular locations, a phenomenon which we refer to as dual targeting or dual localization. The yeast aconitase gene ACO1 (778 amino acids), encodes a single translation product that is nonetheless dual localized to the cytosol and mitochondria by a reverse translocation mechanism. The solved crystal structure of aconitase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cytosol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to HSP70 Heat-Shock Proteins

Share to Protein Conformation, alpha-Helical

Share to Protein Conformation, beta-Strand

Share to Protein Interaction Domains and Motifs

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 29651044
DOI: 10.1038/s41598-018-24068-w
PMCID: PMC5897410

Genes

ACO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70).PMID 29651044Read ↗

Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.Semantic proximity Read ↗

Detection of Dual Targeting and Dual Function of Mitochondrial Proteins in Yeast.Semantic proximity Read ↗

MTALTCO1: a 259 amino-acid long mtDNA-encoded alternative protein that challenges conventional understandings of mitochondrial genomicsSemantic proximity Read ↗

Aconitase couples metabolic regulation to mitochondrial DNA maintenance.Semantic proximity Read ↗

Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing.Semantic proximity Read ↗

Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein importSemantic proximity Read ↗

Essential function of Aco2, a fusion protein of aconitase and mitochondrial ribosomal protein bL21, in mitochondrial translation in fission yeast.Semantic proximity Read ↗

Structure and function of Pet100p, a molecular chaperone required for the assembly of cytochrome c oxidase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structure determination and dual targeting of a plant TACO1 identifies its ancient role as an organelle translation regulatorSemantic proximity Read ↗

A molecular switch in NAC prevents mitochondrial protein mistargeting by SRPSemantic proximity Read ↗

Mitochondrial protein import clogging as a mechanism of diseaseSemantic proximity Read ↗

Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.