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Article

Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease.

Alimentary pharmacology & therapeutics - 1 Sept 2007

Van Dieren J M, Hansen B E, Kuipers E J, Nieuwenhuis E E S, Van der Woude C J

Abstract excerpt

BACKGROUND: Thiopurines are widely used for the treatment of inflammatory bowel disease, but are associated with the development of side effects. It has been suggested that the enzyme inosine triphosphate pyrophosphatase (ITPA) plays a role in the digestion of thiopurines and that defective activ...

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Source

Identifiers

PMID: 17697198
DOI: 10.1111/j.1365-2036.2007.03412.x

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17697198-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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