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Article

Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR

1 Jan 2007

Abstract excerpt

AIM: To study the effect of the toxic secondary bile acid lithocholic acid (LCA) on the expression of fibroblast growth factor 19 (FGF19) in intestinal cells and to characterize the pregnane-X-receptor (PXR) response of the FGF19 promoter region. METHODS: The intestinal cell line LS174T was stimulated with various concentrations of chenodeoxy-cholic acid and lithocholic acid for several time points. FGF19 mRNA...

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PMID: 17696253
DOI: 10.3748/wjg.v13.i31.4230

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