Article
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.
Nature medicine - 1 Sept 2007
Zhang Liyong, Anglesio Michael S, O'Sullivan Maureen, Zhang Fan, Yang Ge, Sarao Renu, Mai P Nghiem, Cronin Shane, Hara Hiromitsu, Melnyk Nataliya, Li Liheng, Wada Teiji, Liu Peter P, Farrar Jason, Arceci Robert J, Sorensen Poul H, Penninger Josef M
Abstract excerpt
Transformation and cancer growth are regulated by the coordinate actions of oncogenes and tumor suppressors. Here, we show that the novel E3 ubiquitin ligase HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of HACE1 in mice results in the development of spontaneous, late-onset cancer. A second hit from either...
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