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Article

Effect of different growth hormone (GH) mutants on the regulation of GH-receptor gene transcription in a human hepatoma cell line.

European journal of endocrinology - 1 Apr 2002

Deladoëy Johnny, Gex Grégoire, Vuissoz Jean-Marc, Strasburger Christian J, Wajnrajch Michael P, Mullis Primus E

Abstract excerpt

OBJECTIVE: G to A transition at position 6664 of the growth hormone (GH-1) gene results in the substitution of Arg183 by His (R183H) in the GH protein and causes a new form of autosomal dominant isolated GH deficiency (IGHD type II). The aim of this study was to assess the bioactivity of this R183H mutant GH in comparison with both other GH variants and the 22-kDa GH in terms of GH-receptor gene regulation....

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Share to Carcinoma, Hepatocellular
Share to Human Growth Hormone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Liver Neoplasms

Share to Molecular Weight

Share to Receptors, Somatotropin

Share to Recombinant Proteins

Share to Transcription, Genetic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 11916628
DOI: 10.1530/eje.0.1460573

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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