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Article

Effect of different growth hormone (GH) mutants on the regulation of GH-receptor gene transcription in a human hepatoma cell line.

European journal of endocrinology - 1 Apr 2002

Deladoëy Johnny, Gex Grégoire, Vuissoz Jean-Marc, Strasburger Christian J, Wajnrajch Michael P, Mullis Primus E

Abstract excerpt

OBJECTIVE: G to A transition at position 6664 of the growth hormone (GH-1) gene results in the substitution of Arg183 by His (R183H) in the GH protein and causes a new form of autosomal dominant isolated GH deficiency (IGHD type II). The aim of this study was to assess the bioactivity of this R18...

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Share to Carcinoma, Hepatocellular
Share to Human Growth Hormone
Share to Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Somatotropin

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Share to Transcription, Genetic

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Source

Identifiers

PMID: 11916628
DOI: 10.1530/eje.0.1460573

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11916628-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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