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Decrease in DNA methylase activity during preimplantation development in the mouse

1 May 1991

Abstract excerpt

During early mouse development, there are large-scale changes in DNA methylation. These changes may be due to the availability or stability of the enzyme, DNA methyltransferase (methylase), which is responsible for maintenance of DNA methylation. A microassay for methylase activity in preimplantation embryos shows that the level of maternally inherited enzyme is extremely high in the egg and that this activity is...

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PMID: 1769327
DOI: 10.1242/dev.112.1.189

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