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Effects of Alzheimer's Disease on Different Cortical Layers: The Role of Intrinsic Differences in Aβ Susceptibility

8 Aug 2007

Abstract excerpt

Alzheimer's disease is late life dementia associated with significant neurodegeneration in both cortical and subcortical regions. During the approximately 10 year course of the disease, neurons are lost in a progressive pattern that is relatively consistent among individuals. One example of this is the progression of disease pathology found in both the neocortex and archicortex. In these structures, the earliest...

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PMID: 17687027
DOI: 10.1523/jneurosci.1008-07.2007

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