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Article

Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication

9 Aug 2007

Abstract excerpt

Alpha/beta interferon (IFN-alpha/beta) produces antiviral effects through upregulation of many interferon-stimulated genes (ISGs) whose protein products are effectors of the antiviral state. Previous data from our laboratory have shown that IFN-alpha/beta can limit Sindbis virus (SB) replication through protein kinase R (PKR)-dependent and PKR-independent mechanisms and that one PKR-independent mechanism inhibits...

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PMID: 17686841
DOI: 10.1128/jvi.01282-07

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