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Article

Haloalkylamine-induced renal papillary necrosis: a histopathological study of structure-activity relationships.

International journal of experimental pathology - 1 Dec 1991

Powell C J, Grasso P, Ioannides C, Wilson J, Bridges J W

Abstract excerpt

The haloalkylamine 2-bromoethanamine (BEA) causes necrosis of renal papillae of rats within 24 h of a single intraperitoneal dose greater than or equal to 100 mg/kg. Nine structural analogues of BEA, differing by halide substitution, alkyl chain elongation or amine substitution, were tested for their ability to induce renal papillary lesions in rats. Three compounds (2-chloroethanamine, 3-bromopropanamine and...

Topics

Animals
Dose-Response Relationship, Drug
Ethylamines
Kidney Medulla
Kidney Papillary Necrosis
Male
Mutation
Rats
Rats, Inbred Strains
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1768609
PMCID: PMC2002440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1768609-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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