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Selective Regulation of Bone Cell Apoptosis by Translational Isoforms of the Glucocorticoid Receptor

7 Aug 2007

Abstract excerpt

Glucocorticoids are widely used in the treatment of inflammatory and other diseases. However, high-dose or chronic administration often triggers troublesome side effects such as metabolic syndrome and osteoporosis. We recently described that one glucocorticoid receptor gene produces eight translational glucocorticoid receptor isoforms that have distinct gene-regulatory abilities. We show here that specific, but...

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PMID: 17682054
DOI: 10.1128/mcb.00253-07

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