Article
Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy.
Epilepsy research - 1 Aug 2007
Chabrol Elodie, Gourfinkel-An Isabelle, Scheffer Ingrid E, Picard Fabienne, Couarch Philippe, Berkovic Samuel F, McMahon Jacinta M, Bajaj Nandita, Mota-Vieira Luisa, Mota Rui, Trouillard Oriane, Depienne Christel, Baulac Michel, LeGuern Eric, Baulac Stéphanie
Abstract excerpt
Mutations in the LGI1 (leucine-rich, glioma inactivated 1) gene are found in less than a half of the families with autosomal dominant lateral temporal epilepsy (ADLTE), suggesting that ADLTE is a genetically heterogeneous disorder. Recently, it was shown that LGI1 is released by neurons and becomes part of a protein complex at the neuronal postsynaptic density where it is implicated in the regulation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.