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Article

Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications.

Journal of gastroenterology and hepatology - 1 Feb 2019

Yeap Sze Pheh, Harley Hugh, Thompson Richard, Williamson Kate Diana, Bate John, Sethna Farah, Farrell Geoffrey, Hague William Bill

Abstract excerpt

BACKGROUND AND AIMS: Clinical syndromes associated with biallelic mutations of bile acid (BA) transporters usually present in childhood. Subtle mutations may underlie intrahepatic cholestasis of pregnancy (ICP) and oral contraceptive steroid (OCS) induced cholestasis. In five women with identified genetic mutations of such transporters, with eight observed pregnancies complicated by ICP, we examined relationships...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Acids and Salts

Share to Cholestasis, Intrahepatic

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Share to Pregnancy Complications

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Source

Identifiers

PMID: 29992621
DOI: 10.1111/jgh.14376

Genes

ABCB4
ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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