Article
Gold causes genetically determined autoimmune and immunostimulatory responses in mice.
Clinical and experimental immunology - 1 Oct 2007
Havarinasab S, Johansson U, Pollard K M, Hultman P
Abstract excerpt
Natrium aurothiomaleate (GSTM) is a useful disease-modifying anti-rheumatic drug, but causes a variety of immune-mediated adverse effects in many patients. A murine model was used to study further the interaction of GSTM with the immune system, including induction of systemic autoimmunity. Mice were given weekly intramuscular injections of GSTM and controls equimolar amounts of sodium thiomaleate. The effects of...
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